Also, differences in the reporting of some clinical manifestations analyzed by age group, including diarrhea, constipation, vomiting, and abdominal pain, were found. Trichotillomania was distributed without predominance by age group. Differences between sex and age were found. A total of 110 cases of 98 case report articles were analyzed. A systematic review in the PubMed database, EBSCO, and Scopus, using the terms "Rapunzel syndrome" AND "case report" OR "clinical case." Results. Describe the frequency of signs and symptoms of Rapunzel syndrome in published case reports and present a comparison between the condition at pediatric and adult ages. The trichobezoar, one of the bezoars that most occur in clinical practice, consists of a mass formed by hair due to ingestion of it either deliberately or unintentionally. Rapunzel syndrome involves an unusual form of gastric trichobezoar located from the stomach into the pylorus and extending to the small intestine, and or right colon. KEYWORDS: Cancer pain, methadone, palliative care Proved to be a safe and effective pharmacological therapeutic option in the management ofĬancer pain, presenting advantages in relation to other opioids due to its low toxicity Medicina: Esforço Comum da Promoção da Saúde e Prevenção e Tratamento das Methadone was not toxic, even at higher dosages, such as 120 mg. Finally, three other studies emphasized that, unlike the other opioids, To three days, since the abrupt exchange, on the same day, triggered less relief from cancer That the exchange of morphine/oxycodone for methadone should be done gradually, within up Improvement in pain control with intravenous methadone in a patient with advanced colorectalĬancer who was using a high dose of hydromorphone. Accordingly, another case report observed Of care with monitoring electrocardiographic in its intravenous administration, as cardiacĪrrhythmia proved to be a possible adverse effect. Results and Discussion: Two studies, one randomized and oneĬase report, found methadone to be effective in treating pain in patients with head and neckĬancer, the first study considered it significantly better than fentanyl and the second warned Incomplete studies and those that did not fit the objectives wereĮxcluded, leaving 10 articles. Clinical trials and case reports published in the Was carried out in the PubMed database, with the descriptors: “(Hospice Care OR PalliativeĬare) AND Cancer Pain AND Methadone”. Methodology: A systematic review of the literature Important to reduce pain in these patients. In clinical practice, being methadone, a second-line drug, an alternative to morphine, very IN PALLIATIVE CARE: A SYSTEMATIC REVIEW OF THE LITERATUREĪBSTRACT: Introduction: The management of cancer pain in palliative care is a challenge METHADONE IN THE MANAGEMENT OF REFRACTORY ONCOLOGICAL PAIN
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